Open the brandy with the game and get drunk (6)
I believe the answer is:
blotto
'drunk' is the definition.
(slang term)
'open the brandy with the game' is the wordplay.
'open' suggests taking the first letters (take the opening letter).
'with' means one lot of letters goes inside another.
'the' becomes 't' (the is pronounced as a 't' sound in some dialects).
'game' becomes 'loto' (I've seen this before).
The initial letter of 'brandy' is 'b'.
't' put within 'loto' is 'lotto'.
'b'+'lotto'='BLOTTO'
'and get' is the link.
(Other definitions for blotto that I've seen before include "under the table" , "Plastered, hammered, sloshed" , "As one plastered" , "Slangily drunk - ready to bolt" , "Blind drunk" .)