Open University stirred up great indignation (7)
I believe the answer is:
outrage
'indignation' is the definition.
(outrage can mean indignation or fury)
'open university stirred up great' is the wordplay.
'open university' becomes 'OU'.
'stirred up' is an anagram indicator (letters get stirred up or mixed).
'great' with letters rearranged gives 'trage'.
'ou'+'trage'='OUTRAGE'
(Other definitions for outrage that I've seen before include "Gross injury" , "Fury" , "Act that shocks public opinion, generates anger" , "Strong reaction of anger or indignation" , "A feeling of righteous anger" .)