Opening without latest lead actor (4)
I believe the answer is:
star
'lead actor' is the definition.
(eg the star of a show)
'opening without latest' is the wordplay.
'opening' becomes 'start' (I've seen this before).
'without latest' means to remove the last letter (the last or latest letter is removed).
'start' with its last letter taken off is 'STAR'.
(Other definitions for star that I've seen before include "Polaris, possibly" , "Celebrity in the world of entertainment" , "Five- or six-pointed figure" , "Top-of-the-bill artist" , "''Twinkle, twinkle, little ...'' (children's song)" .)