Opens up and cleans out (6)
I believe the answer is:
lances
'opens up' is the definition.
(lancing is a kind of opening up)
'cleans out' is the wordplay.
'out' indicates an anagram (out can mean wrong or inaccurate).
'cleans' anagrammed gives 'LANCES'.
'and' is the link.
(Other definitions for lances that I've seen before include "Spears for cavalrymen" , "Long pointed weapons" , "Spears for horse soldiers" .)