Oppose opening nightclub around your suburb, annoying youths (6)
I believe the answer is:
naysay
'oppose' is the definition.
(naysayers oppose something)
'opening nightclub around your suburb annoying youths' is the wordplay.
'opening' suggests taking the first letters.
The first letters of 'nightclub around your suburb annoying youths' is 'NAYSAY'.
(Other definitions for naysay that I've seen before include "Deny" , "refusal" , "refuse" .)