Opposed to a saint accepting profit (7)
I believe the answer is:
against
'opposed to' is the definition.
(I've seen this before)
'a saint accepting profit' is the wordplay.
'saint' becomes 'st' (abbreviation).
'accepting' is an insertion indicator (inserted letters are accepted).
'profit' becomes 'gain' (synonyms).
'a'+'st'='ast'
'ast' going around 'gain' is 'AGAINST'.
(Other definitions for against that I've seen before include "Anti, touching" , "Facing" , "Opposing" , "In opposition to" , "Opposed" .)