Opposed to making a profit on the way (7)
I believe the answer is:
against
'opposed to' is the definition.
(I've seen this before)
'a profit on the way' is the wordplay.
'profit' becomes 'gain' (synonyms).
'on' means one lot of letters go next to another.
'the way' becomes 'st' (abbreviation for street).
'a'+'gain'+'st'='AGAINST'
'making' is the link.
(Other definitions for against that I've seen before include "antagonistic" , "In conflict with" , "Abutting" , "In contrast to; touching" , "Not favouring" .)