Opposite sides with row in the middle between spells trouble (3)
I believe the answer is:
woe
'trouble' is the definition.
(I've seen this before)
'opposite sides with row' is the wordplay.
'sides' says to hollow out the word (remove centre letters) (only the letters on the sides are used).
'with' becomes 'w' (abbreviation).
'row' is an anagram indicator.
'opposite' with its middle removed is 'oe'.
'oe'+'w'='oew'
'oew' anagrammed gives 'WOE'.
'in the middle between spells' acts as a link.
This may not be correct. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for woe that I've seen before include "Misfortune" , "Misery, wretchedness" , "Misery, great suffering" , "Tale content?" , "Grief, misery" .)