Orangemen lacking gene originating in Italy
I believe the answer is:
roman
'orangemen lacking gene originating' is the definition.
I can't tell whether this defines the answer.
'in italy' is the wordplay.
I cannot really understand how this works, but
'in italy' could be 'roma' ('Roma' is part of 'italy') and 'roma' is located in the answer.
A single letter 'n' remains which might be clued in a way I don't see.
This may be the basis of clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for roman that I've seen before include "- Catholic; - candle" , "A novel" , "Countryman of Mark Antony" , "Of an Italian city" , "Plain upright print style" .)