Orchestrated tuba with E-minor instrument (10)
I believe the answer is:
tambourine
'instrument' is the definition.
(tambourine is a kind of instrument)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for tambourine that I've seen before include "Shaken instrument" , "drum" , "Percussion instrument" , "One uses jingles" .)