Order great changes, making things worse (10)
I believe the answer is:
retrograde
'making things worse' is the definition.
(as in a retrograde move)
'order great changes' is the wordplay.
'changes' is an anagram indicator.
'order'+'great'='ordergreat'
'ordergreat' with letters rearranged gives 'RETROGRADE'.
(Other definitions for retrograde that I've seen before include "Moving backwards" , "Reactionary" , "inverse" , "Going back" , "Backward" .)