Organs of state heartlessly start on immigrants (5)
I believe the answer is:
uteri
'organs' is the definition.
(plural of uterus)
'state heartlessly start on immigrants' is the wordplay.
'state' becomes 'utter' (both can mean to say).
'heartlessly' says to hollow out the word (remove centre letters).
'start on' indicates taking the first letters (I've seen 'starts on' mean this).
'utter' with its centre removed is 'uter'.
The initial letter of 'immigrants' is 'i'.
'uter'+'i'='UTERI'
'of' is the link.
(Other definitions for uteri that I've seen before include "several organs" , "Developing places" , "Wombs" , "baby carriers" , "organs, in hospital patients" .)