Orpheus played one (4)
I believe the answer is:
lyre
'orpheus played one' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for lyre that I've seen before include "Ancient Greek harp" , "Music-maker" , "Instrument played by Orpheus" , "Ancient harp-like instrument" , "Sort of harp" .)