Othello manipulator (4)
I believe the answer is:
iago
'othello manipulator' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for iago that I've seen before include "villain in play" , "The villain who tricked Othello" , "Othello's Ancient" , "Othello's enemy" , "Shakespeare's jealous villain" .)