Out of bed and suffering -- honest (10)
I believe the answer is:
upstanding
'honest' is the definition.
(thesaurus)
'out of bed and suffering' is the wordplay.
'out of bed' becomes 'up' ('up' can be a synonym of 'out of bed').
'and' means one lot of letters go next to another.
'suffering' becomes 'standing' ('stand' can be a synonym of 'suffer').
'up'+'standing'='UPSTANDING'
(Other definitions for upstanding that I've seen before include "as we must be when the judge appears!" , "Ready for toast" , "Honest, respectable; erect" .)