Out of bed, drunk is nervy (7)
I believe the answer is:
uptight
'is nervy' is the definition.
(synonyms)
'out of bed drunk' is the wordplay.
'out of bed' becomes 'up' (synonyms).
'drunk' becomes 'tight' (slang term).
'up'+'tight'='UPTIGHT'
(Other definitions for uptight that I've seen before include "On edge" , "edgy" , "Repressed and disapproving" , "Showing repressed anxiety or anger" , "Ill at ease" .)