Out of control, they rail with gusto (8)
I believe the answer is:
heartily
'with gusto' is the definition.
(thesaurus)
'out of control they rail' is the wordplay.
'out of control' indicates an anagram.
'they'+'rail'='theyrail'
'theyrail' anagrammed gives 'HEARTILY'.
(Other definitions for heartily that I've seen before include "Enthusiastically" , "To a great degree" , "With gusto and without reservation" , "With vigour" , "thoroughly" .)