Out of shape with run coming up (4)
I believe the answer is:
port
'out' is the definition.
(thesaurus)
'shape with run coming up' is the wordplay.
'shape' becomes 'top' (top is a kind of shape).
'with' is an insertion indicator.
'run' becomes 'r' (cricket abbreviation).
'coming up' says the letters should be written backwards.
'top' placed around 'r' is 'trop'.
'trop' reversed gives 'PORT'.
'of' acts as a link.
(Other definitions for port that I've seen before include "Stanley perhaps" , "Larboard, formerly" , "Sweet dark red fortified wine taken after meal" , "After-dinner wine" , "Bordeaux, say" .)