Out to make one uneasy? (3,2,4)
I believe the answer is:
not at home
'out' is the definition.
(I've seen this before)
'one uneasy?' is the wordplay.
I cannot really see how this works, but
'one' could be 'me' (a setter might use 'one' to humourously mean 'me') and 'me' is found within the answer.
This may be the basis of the clue (or it may be nonsense).
'to make' is the link.
Can you help me to learn more?
(Other definitions for not at home that I've seen before include "barking at the moon" , "Ignoring visitors" .)