Oversensitive youth, nervous about college (6)
I believe the answer is:
touchy
'oversensitive' is the definition.
(I've seen this before)
'youth nervous about college' is the wordplay.
'nervous' is an anagram indicator (letters get shaken up).
'about' means one lot of letters goes inside another.
'college' becomes 'c'.
'youth' anagrammed gives 'touhy'.
'touhy' placed around 'c' is 'TOUCHY'.
(Other definitions for touchy that I've seen before include "Easily offended in tactile way?" , "Quick to take offence" , "Quick-tempered" , "Irascible" , "sensitive" .)