Overused story following saint primarily (5)
I believe the answer is:
stale
'overused' is the definition.
(thesaurus)
'story following saint primarily' is the wordplay.
'story' becomes 'tale' (synonyms).
'following' means one lot of letters go next to another.
'primarily' indicates taking the first letters.
The initial letter of 'saint' is 's'.
'tale' put after 's' is 'STALE'.
(Other definitions for stale that I've seen before include "No longer fresh" , "piss" , "Musty or hackneyed" , "past the sell-by date" , "Not fresh, being least" .)