Pa and me three times made crazy effort (7)
I believe the answer is:
attempt
'crazy effort' is the definition.
'attempt' can be an answer for 'effort' (synonyms). I'm unsure of the 'crazy' bit.
'pa and me three times made' is the wordplay.
'three times' can mean three substitutions for 'time'.
'and' means one lot of letters go next to another.
'time' becomes 't' (abbreviation).
'time' becomes 't' (abbreviation).
'time' becomes 't' (abbreviation).
'made' indicates an anagram.
'pa'+'me'+'t'+'t'+'t'='pamettt'
'pamettt' with letters rearranged gives 'ATTEMPT'.
Can you help me to learn more?
(Other definitions for attempt that I've seen before include "Embark on, try" , "Have a crack" , "bash" , "Undertake" , "Try to climb (a peak)" .)