Pa and me three times making effort (7)
I believe the answer is:
attempt
'effort' is the definition.
(synonyms)
'pa and me three times making' is the wordplay.
'three times' can mean three substitutions for 'time'.
'and' means one lot of letters go next to another.
'time' becomes 't' (abbreviation).
'time' becomes 't' (abbreviation).
'time' becomes 't' (abbreviation).
'making' indicates anagramming the letters.
'me'+'t'+'t'+'t'='mettt'
'pa' after 'mettt' is 'metttpa'.
'metttpa' anagrammed gives 'ATTEMPT'.
(Other definitions for attempt that I've seen before include "bash" , "Try, endeavour" , "Have a crack" , "Tackle" , "Embark on, try" .)