Pain arranging wig net (6)
I believe the answer is:
twinge
'pain' is the definition.
(twinge is a kind of pain)
'arranging wig net' is the wordplay.
'arranging' indicates anagramming the letters.
'wig'+'net'='wignet'
'wignet' anagrammed gives 'TWINGE'.
(Other definitions for twinge that I've seen before include "Small pain eg from conscience" , "Sudden localised pain" , "A small pang, of pain or concience" , "Slight ache" , "Sudden sharp pain" .)