Pain is in fine detail (8)

I believe the answer is:

nuisance

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'pain' is the definition.
(synonyms)

'is in fine detail' is the wordplay.
'in' indicates putting letters inside.
'fine detail' becomes 'nuance' (I can't explain this - if you can you should give a lot more credence to this answer).
'is' going within 'nuance' is 'NUISANCE'.

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(Other definitions for nuisance that I've seen before include "Annoying or troublesome person or thing" , "Bothersome annoying person" , "Tiresome person or event" , "Annoying person/thing" , "Bothersome pest" .)

I've seen this clue in The Telegraph.

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