Pain of blindworms on top of house (7)
I believe the answer is:
anguish
'pain' is the definition.
(anguish is pain or suffering)
'of blindworms on top of house' is the wordplay.
'of blindworms' becomes 'anguis' (I can't explain this - if you can you should give a lot more credence to this answer).
'on top of' indicates taking the first letters.
The first letter of 'house' is 'h'.
'anguis'+'h'='ANGUISH'
Can you help me to learn more?
(Other definitions for anguish that I've seen before include "Extreme torment" , "Great (mental) pain" , "Severe mental suffering" , "Grief" , "Angst" .)