Pain of one of those giants from Bunyan's The Pilgrim's Progress (7)

I believe the answer is:

despair

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'pain' is the definition.
(thesaurus)

I don't understand how the remainder of the clue works.

(Other definitions for despair that I've seen before include "Complete absence of hope" , "First appearance" , "Opposite of 10" , "Total loss of hope" , "Abandon hope" .)

I've seen this clue in the Irish Times and the Irish Times (Crosaire).

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