Painkillers? Yes and no, unfortunately (8)
I believe the answer is:
anodynes
'painkillers?' is the definition.
('anodyne' can be a synonym of 'painkiller')
'yes and no unfortunately' is the wordplay.
'unfortunately' indicates anagramming the letters.
'yes'+'and'+'no'='yesandno'
'yesandno' anagrammed gives 'ANODYNES'.
(Other definitions for anodynes that I've seen before include "They relieve pain" , "Painkillers" .)