Painstaking preparation (7)
I believe the answer is:
codeine
'painstaking preparation' is the definition.
Although both the answer and definition are singular nouns, I cannot see how one could define the other.
This is all the clue.
Can you help me to learn more?
(Other definitions for codeine that I've seen before include "Painkiller derived from opium" , "Pain-relieving derivative of opium" , "An anodyne" , "Common opium-based tablet used to relieve pain" , "Common painkiller" .)