Painter humble with the second-hand exchange? (5)
I believe the answer is:
lowry
'painter' is the definition.
(I've seen this before)
'humble with the second-hand exchange?' is the wordplay.
'humble' becomes 'low' (similar in meaning).
'with' means one lot of letters go next to another.
'the second hand exchange?' becomes 'ry' (I can't justify this - if you can you should believe this answer much more).
'low'+'ry'='LOWRY'
Can you help me to learn more?
(Other definitions for lowry that I've seen before include "L. S. -, English artist" , "Painter of bleak scenes" , "Painter of industrial Lancashire" , "English painter noted for his stick people" , "Painter noted for his matchstick figures" .)