Pairs of lines set out across and down to start work (8)
I believe the answer is:
couplets
'pairs' is the definition.
('couplet' can be a synonym of 'pair')
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for couplets that I've seen before include "Pairs of consecutive lines of verse" , "Pairs of rhyming lines of verse" .)