Parents accommodate heading for Rome (Italian city) (5)
I believe the answer is:
parma
'italian city' is the definition.
(I've seen this before)
'parents accommodate heading for rome' is the wordplay.
'parents' becomes 'pama' (Pa and Ma).
'accommodate' is an insertion indicator.
'heading for' suggests taking the first letters.
The first letter of 'rome' is 'r'.
'pama' enclosing 'r' is 'PARMA'.
(Other definitions for parma that I've seen before include "Source of ham and cheese" , "Italian city noted for ham" , "Here in Italy" , "It. ham city; its Charterhouse, Stendhal" , "Italian city producing cured ham" .)