Part of reply, in general dishonest (5)
I believe the answer is:
lying
'dishonest' is the definition.
('lying' can be a synonym of 'dishonest')
'part of reply in general' is the wordplay.
'part of' indicates a hidden word.
'LYING' can be found hidden inside 'reply in general'.
(Other definitions for lying that I've seen before include "Prostrate -- prone" , "not to be trusted?" , "retailing pork pies" , "Spread out" , "Not standing" .)