Partial smirk, so memorably tedious (7)
I believe the answer is:
irksome
'tedious' is the definition.
(I've seen this before)
'partial smirk so memorably' is the wordplay.
'partial' indicates the answer is hidden within the clue.
'IRKSOME' can be found hidden inside 'smirk so memorably'.
(Other definitions for irksome that I've seen before include "'Tedious, tiresome (7)'" , "Smoker I find annoying" , "bugging" , "Annoying or tiresome" , "Annoying - tedious" .)