Particularly doctors have to take a decrease (4,2,3)
I believe the answer is:
most of all
'particularly' is the definition.
Both the definition and answer are adverbs. Maybe you can see an association between them that I can't see?
'doctors have to take a decrease' is the wordplay.
'doctors' becomes 'mos' (an MO is a Medical Officer).
'have' is a charade indicator (letters next to each other).
'take' means one lot of letters go next to another.
'a decrease' becomes 'fall' (fall is a kind of decrease).
'mos'+'to'+'fall'='MOST OF ALL'
Can you help me to learn more?
(Other definitions for most of all that I've seen before include "having greatest importance" , "Nearly everyone" , "Chiefly" .)