Party chief's area of knowledge (6)
I believe the answer is:
domain
'area of knowledge' is the definition.
'domain' can be an answer for 'area' (synonyms). I am not certain of the 'of knowledge' bit.
'party chief's' is the wordplay.
'party' becomes 'do' (do is a kind of party).
'chief' becomes 'main' (synonyms).
'do'+'main'='DOMAIN'
Can you help me to learn more?
(Other definitions for domain that I've seen before include "Sphere or territory" , "Territory over which someone reigns" , "Special region, area of expertise" , "Kingdom or realm" , "Scope of knowledge - owned land" .)