Perfume from a city in Italy (5)
I believe the answer is:
aroma
'perfume' is the definition.
(synonyms)
'a city in italy' is the wordplay.
'city in italy' becomes 'Roma' (Italian name for Rome).
'a'+'roma'='AROMA'
'from' acts as a link.
(Other definitions for aroma that I've seen before include "Distinctive scent" , "Strong smell" , "Pleasant odour" , "Agreeable odour" , "Scent - smell" .)