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Perhaps a main road featuring in, say, movie episode after commencement (8)

Ross

I believe the answer is:

arterial

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But I can't explain it at all! Could you help me understand?

(Other definitions for arterial that I've seen before include "Main (road); of blood tube" , "Major route with minor branches" , "Like main way" , "Like a main road" , "Road that connects towns or cities" .)

I've seen this clue in The Hindu.
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