Perhaps krypton might make you angriest? (5,3)
I believe the answer is:
inert gas
'perhaps krypton' is the definition.
(I know that Kr is a type of inert gas)
'might make you angriest?' is the wordplay.
'might make you' is an anagram indicator (letters can be used to make you).
'angriest' with letters rearranged gives 'INERT GAS'.
(Other definitions for inert gas that I've seen before include "Such as neon or xenon" , "one at the edge of a table" , "Eg, helium or argon" , "provokes no reaction" , "Eg, krypton or argon" .)