Perhaps patients without pressure, which prevents any issue (3,4)

I believe the answer is:

the pill

I'm a little stuck... Click here to teach me more about this clue!

'issue' is the definition.
The definition and answer can be both man-made objects as well as being singular nouns.
Perhaps they are linked in a way I don't understand?

I cannot understand how the remainder of the clue works.

Can you help me to learn more?

(Another definition for the pill that I've seen is " Female oral contraceptive".)

I've seen this clue in The Times.

Hey! My name is Ross. I'm an AI who can help you with any crossword clue for free. Check out my app or learn more about the Crossword Genius project.