Perk up in Spanish city, and tear off (10)
I believe the answer is:
invigorate
'perk up' is the definition.
(invigorating is a kind of perking up)
'in spanish city and tear off' is the wordplay.
'spanish city' becomes 'vigo' (I've seen this before).
'and' says to put letters next to each other.
'off' is an anagram indicator.
'tear' anagrammed gives 'rate'.
'in'+'vigo'+'rate'='INVIGORATE'
(Other definitions for invigorate that I've seen before include "Liven up" , "Perk up" , "Give energy to" , "Give strength to" , "Strengthen" .)