Pick English literature course, ultimately (5)
I believe the answer is:
elite
'pick' is the definition.
(I've seen this before)
'english literature course ultimately' is the wordplay.
'english' becomes 'e' (abbreviation).
'literature' becomes 'lit'.
'ultimately' indicates one should take the final letters.
The last letter of 'course' is 'e'.
'e'+'lit'+'e'='ELITE'
(Other definitions for elite that I've seen before include "Cream, the pick" , "A privileged group in society" , "top drawer?" , "Select part" , "Upper crust" .)