Pick fruit around Crete, mostly fresh (8)
I believe the answer is:
plectrum
'pick' is the definition.
(a guitar pick)
'fruit around crete mostly fresh' is the wordplay.
'fruit' becomes 'plum' (plum is a kind of fruit**).
'around' indicates putting letters inside.
'mostly' means to remove the last letter.
'fresh' indicates an anagram.
'crete' with its final letter removed is 'cret'.
'cret' with letters rearranged gives 'ectr'.
'plum' going around 'ectr' is 'PLECTRUM'.
(Other definitions for plectrum that I've seen before include "It's used to pluck, a guitar say" , "Device for plucking strings of an instrument" , "Guitarist's aid" , "Guitar pick" , "Implement for plucking guitar strings" .)