Pick up courage no end (4)
I believe the answer is:
hear
'pick up' is the definition.
(hearing is a kind of picking up)
'courage no end' is the wordplay.
'courage' becomes 'heart' (heart is a kind of courage).
'no end' means to remove the last letter.
'heart' with its last letter removed is 'HEAR'.
(Other definitions for hear that I've seen before include "Listen to" , "Catch" , "Perceive aurally" , "receive information" , "Pay attention" .)