Pick up from a penetrating depression (5)
I believe the answer is:
glean
'pick up' is the definition.
(I've seen this before)
'a penetrating depression' is the wordplay.
'penetrating' indicates putting letters inside.
'depression' becomes 'glen' (glen is a kind of depression).
'a' inserted within 'glen' is 'GLEAN'.
'from' is the link.
(Other definitions for glean that I've seen before include "Angel (anag.)" , "Gather after reaping" , "Reap as harvest" , "Gradually put together" , "Collect bit by bit, often with difficulty" .)