Pick up in a way that's touching (7)
I believe the answer is:
against
'that's touching' is the definition.
(eg leaning against something)
'pick up in a way' is the wordplay.
'pick up' becomes 'gain' (I've seen this before).
'in' means one lot of letters goes inside another.
'way' becomes 'st' (abbreviation for street).
'a'+'st'='ast'
'gain' inserted into 'ast' is 'AGAINST'.
(Other definitions for against that I've seen before include "In disagreement with" , "V" , "In opposition to" , "In contrast to; touching" , "Opposite to" .)