Pick up sensei and drop one (5)
I believe the answer is:
sense
'pick up' is the definition.
(synonyms)
'sensei and drop one' is the wordplay.
I cannot really see how this works, but
'and' could be 'n' (common abbreviation for 'and') and 'n' is present in the answer.
The remaining letters 'sese' is a valid word which might be clued in a way I don't understand.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for sense that I've seen before include "experience" , "Feel intuitively" , "Hearing maybe" , "A particular meaning" , "Awareness" .)