Pierce, male friend in centre of Amiens (6)
I believe the answer is:
impale
'pierce' is the definition.
(pierce can mean to impale)
'male friend in centre of amiens' is the wordplay.
'male' becomes 'm' (common abbreviation).
'friend' becomes 'pal' (pal can mean a friend).
'in' means one lot of letters goes inside another.
'centre of' means to look at the middle letters.
The middle of 'amiens' is 'ie'.
'm'+'pal'='mpal'
'mpal' put into 'ie' is 'IMPALE'.
(Other definitions for impale that I've seen before include "Transfix with spear" , "Pierce, run through" , "Pierce with a stick (as Vlad did?)" , "Spike" , "Pierce through as with sharp stick" .)