Pigments come wrapped, making them difficult to handle (10)
I believe the answer is:
cumbersome
'them difficult to handle' is the definition.
I can't judge whether this defines the answer.
'pigments come wrapped' is the wordplay.
'pigments' becomes 'umbers' (umber is a kind of pigment).
'wrapped' is an insertion indicator.
'umbers' placed into 'come' is 'CUMBERSOME'.
'making' acts as a link.
Can you help me to learn more?
(Other definitions for cumbersome that I've seen before include "Unwieldy" , "Awkward" .)