Piloted in over a city in Spain (6)
I believe the answer is:
toledo
'a city in spain' is the definition.
I can't tell whether this defines the answer.
'piloted in over' is the wordplay.
'piloted' becomes 'led' (pilot can mean to lead or guide).
'in' indicates putting letters inside.
'over' becomes 'too' (I've seen this before).
'led' placed within 'too' is 'TOLEDO'.
Can you help me to learn more?
(Other definitions for toledo that I've seen before include "Sword; city in Ohio" , "Looted the Spanish city badly" , "Blade" , "Spanish city, famous for steel and swords" , "To dole out in the Spanish city" .)